“It’s likely a viral or bacterial infection,” says Toribio Flores, MD, ear, nose, and throat (ENT) specialist for the Cleveland Clinic’s Head and Neck Institute at Independence Health Center in Ohio. A sore throat can take many forms — it can be scratchy or itchy, burn, or cause painful swallowing. Many times a sore throat is accompanied by a pesky cough which can irritate the tender throat even more. Many common colds and viruses can cause a sore throat that typically subsides within a few days. But when a sore throat persists and you can’t find relief, it’s something to take seriously. Some possible causes of a chronic sore throat include:

Tonsillitis (infection of the tonsils)Strep throatAllergiesMononucleosis (also referred to as mono)Inhaling air pollutantsSmokingInfluenza (the flu)Inhaling through the mouth instead of the nose

Some of these conditions, like the flu, may be fairly minor and not require treatment, while strep throat and tonsillitis can turn into serious health problems if left untreated. In addition, Flores notes that persistent throat pain on one side — or that feels worse on one side — may indicate a bacterial infection that usually begins as a complication of tonsillitis or untreated strep throat (peritonsillar abscess). In some cases, the pain may indicate an advanced tumor. “A sore throat accompanied by a swollen neck gland should be seen by a physician soon,” says Flores. Other causes of a chronic sore throat, like smoking, are problems that you can control to alleviate your throat pain.

The Best Ways to Treat a Sore Throat

To successfully treat a sore throat, you have to know what’s causing it. Bacterial infections like strep throat need treatment with antibiotics. It’s crucial that you receive treatment for strep and don’t let it continue. This bacterial infection can lead to rheumatic fever, which can cause permanent heart damage. A simple course of antibiotics (remember to take them all) can keep strep throat from becoming a serious problem. Viral infections, like influenza, may be treated with antiviral medication, but most do not require any treatment at all. If you have allergies that are causing a chronic sore throat (through postnasal drip), your doctor may prescribe a medication to control allergy symptoms, such as nasal corticosteroids like Flonase (fluticasone). You can also find ways to avoid those allergens (often things like mold, pet dander, or pollen) to alleviate your throat pain and other symptoms. RELATED: How Long Does a Cold or the Flu Last?

Finding Relief From Throat Pain

No matter what’s causing a sore throat, you can take steps at home to soothe an itchy, scratchy, painful throat. Try these tips to relieve throat pain at home:

Suck on something soothing, like a piece of hard candy, a throat lozenge, or a Popsicle.Stay hydrated and moisten the throat by drinking plenty of water and other fluids. Try adding honey to a warm drink or sip on a mug of warm tea.Try an over-the-counter pain reliever, such as Aleve (naproxen), Tylenol (acetaminophen), and Advil or Motrin (ibuprofen). Use in moderation and only for a short period of time.Run a humidifier in your home to prevent dry air from irritating your throat.Create a mixture of warm water and 1 teaspoon of salt per cup and gargle it a couple of times per day.

It can be hard to pinpoint the cause of a sore throat, but if it doesn’t get any better, you can be sure there’s some reason for it. “If the sore throat is accompanied by very severe pain on swallowing along with a high fever, it’s best to see a healthcare provider right away,” says Flores. See your doctor, figure out the cause, and decide on treatments and remedies that best fit your diagnosis.