ConstipationGasStrep throatSwallowing lots of airAnxietyA mild food allergyA stomach or intestinal infection (gastroenteritis)

If your child’s stomachache intensifies or lasts for more than a day, it could be a sign of a serious condition. But again, there’s a long list of diseases that could cause this abdominal pain, including: Appendicitis most often affects teens and those in their twenties, but it can occur in children as well. According to the Cleveland Clinic, approximately 70,000 children in the United States are affected each year. (3) It’s usually caused by an abdominal infection that has spread to the appendix, or by a blockage that has obstructed the appendix. If your child’s abdominal pain worsens with movement, deep breaths, coughing, or sneezing, the possibility that he or she has appendicitis should be seriously considered. Still, it’s important to look for other signs of appendicitis.

The Signs and Symptoms of Appendicitis in Children

In most adults, there is a very specific set of appendicitis symptoms that accompany abdominal pain. These often include:

Loss of appetiteNauseaVomitingLow-grade feverInability to pass gas or stoolAbdominal swellingConstipation or diarrhea

But research suggests that appendicitis can affect children differently than adults. Along with abdominal pain, most kids with appendicitis often experience fever and a symptom known as “rebound tenderness,” (1) a sharp pain that develops after pressure is placed on the lower right abdominal area and quickly released. Children may also have an elevated white blood cell count, which is a sign of an infection. Your doctor can check this with a blood test. (4) Importantly, although some kids with appendicitis do experience other hallmark symptoms of the condition, including nausea, vomiting, and lack of appetite, these signs are not predictive of appendicitis in children. (5) Appendicitis may also cause different sets of symptoms with very young children. Some studies suggest that kids between ages 2 and 5 most often experience stomachaches and vomiting if they have appendicitis; fever and loss of appetite also frequently occur. For infants younger than 2 years old, appendicitis usually causes vomiting, a bloated or swollen abdomen, and fever, though diarrhea is also not uncommon. (6) To confirm a diagnosis of appendicitis, doctors often use imaging procedures. For children, the American College of Radiology recommends performing an ultrasound first, followed by a computed tomography (CT) scan only if the ultrasound is inconclusive. This is due to caution concerning radiation exposure in kids. (7)

Treating Complicated and Uncomplicated Appendicitis in Children

An appendectomy, which involves the surgical removal of the appendix, is the standard treatment for appendicitis in children as well as adults. If appendicitis isn’t caught in its early stages, the appendix can rupture and cause an infection of the peritoneum, the membrane that lines the abdominal cavity. This infection, called peritonitis, can quickly spread, potentially causing death. Because appendicitis is more difficult to diagnose in children than adults — especially in children younger than 5 — some 30 percent of kids with the condition will suffer from a perforated (ruptured) appendix before being treated. (3) And some data suggests that in children younger than 5, it may be up to 51 percent. (8) For kids with acute, nonperforated appendicitis (meaning the appendix hasn’t ruptured), an urgent appendectomy is the accepted, optimal treatment. When the appendix has ruptured, though, there are two surgical courses of action: early appendectomy (performed within 24 hours of admission) or interval appendectomy (performed several weeks later) after antibiotics are used to treat infection. A study notes that there hasn’t been a clear consensus on which is the best way to manage ruptured appendices in children — with conservative treatment (antibiotics followed by interval appendectomy) or early appendectomy. (9) Traditionally, the conservative treatment has been preferred, but other research suggests that kids recover more quickly and are less likely to suffer from post-surgery complications, such as surgical-site infections, if their ruptured appendices are removed within 24 hours of diagnosis. (10) Researchers found that such patients may benefit from early appendectomy, as it could shorten the duration of antibiotics, reduce the need to increase antibiotics, and decrease the length of hospitalization. They note that more research is needed to confirm their findings. (9) When acute appendicitis is uncomplicated, which means it presents without any signs of perforation, there’s increasing evidence supporting antibiotics as an alternative to surgery in adults. Recent studies have also examined if this holds true in pediatric cases. A 2017 meta-analysis of studies found that data suggests nonoperative treatment is safe and effective in children with acute uncomplicated appendicitis. (11) Again, study authors say more research is needed. Clinical trials investigating appendectomy versus nonoperative treatment in children whose appendices are not ruptured are currently underway in the United States and the United Kingdom. (12,13) Additional reporting by Deborah Shapiro.

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